To start, divide yourselves into two teams of two players each, sitting across from each other at a table. Canasta is a captivating and strategic game that combines elements of skill, luck, and teamwork, making it a favorite pastime for many. How To Play Canasta With 4 Players: The exciting world of Canasta! If you have four eager players and are ready for some friendly competition, this classic card game is just the thing for you.